A high-speed robotic screening system, aimed at protecting human health by improving how chemicals are tested in the United States, will test 10,000 compounds for potential toxicity. The compounds cover a wide variety of classifications, and include consumer products, food additives, chemicals found in industrial processes, and human and veterinary drugs. A complete list of the compounds is publicly available at www.epa.gov/ncct/dsstox
Testing this 10,000 compound library begins a new phase of an ongoing collaboration between the National Institutes of Health, the U.S. Environmental Protection Agency, and the U.S. Food and Drug Administration, referred to as Tox21. NIH partners include the National Toxicology Program, administered by the National Institute of Environmental Health Sciences and the NIH Chemical Genomics Center, part of the NIH Center for Translational Therapeutics.
“There has never been a compound library like this before.” – Linda Birnbaum Director
Birnbaum is especially excited that some of the compounds the NTP has brought forward for testing are mixtures of chemicals. “All of us are exposed to many different chemicals at the same time, not just one chemical at a time,” she said. “These new technologies allow us to more rapidly advance our understanding of not only individual chemicals, but mixtures of chemicals as well.”
A subset of the NTP portion of the 10,000 compound library will focus on pilot testing several formulations or mixtures of compounds, a priority area for NIEHS/NTP. The library constituents were selected after a thorough analysis of existing scientific studies, more than 200 public chemical databases, and chemical nominations received from internal and external partners. Each test compound will undergo a thorough chemical analysis to verify its identity and determine its purity, concentration, and stability.
The goal of the testing is to provide results that will be useful for evaluating if these chemicals have the potential to disrupt processes in the human body to an extent that leads to adverse health effects.
The compounds will be tested in the Tox21 robotic screening system at the NCGC in Rockville, Md. The Tox21 robot, unveiled earlier this year, was purchased with funds provided by the NTP as part of its contribution to the Tox21 partnership.
The development of methods for evaluating chemical toxicity has the potential to revolutionize the assessment of new environmental chemicals and the development of new drugs for therapeutic use.
“We are happy to contribute NCGC’s pharmaceutical collection of approximately 3,500 compounds of approved and investigational drugs as part of the Tox21 program,” – Christopher Austin NCTT Scientific Director
“Drug toxicity is one of the primary reasons that the development of new drugs fails and approved drugs are removed from the market, and the ability to better predict toxicity would improve the efficiency of drug development enormously,” he added.
The EPA seeks to understand the molecular basis of such chemicals to better protect human health and that of the environment.
“The Tox21 partnership integrates revolutionary advances in molecular biology, chemistry, and computer science, to quickly and cost-effectively screen the thousands of chemicals in use today.” – Paul Anastas Assistant Administrator EPA Office of Research and Development
The FDA, also a partner in Tox21, emphasizes the value of this effort for the public.
“The Tox21 rapid assessment of drug toxicity can become a powerful safety tool for protecting the American public. It also has the potential to help bring innovative drugs to market by allowing drug developers to identify unsafe candidate drugs early.” – Janet Woodcock, M.D. Director FDA Center Drug Evaluation and Research
All testing results will be available to the public through NIH and EPA chemical toxicity databases. In addition, NCTT has created a Tox21 chemical inventory browser freely available at http://tripod.nih.gov/tox21chem to provide researchers with additional about the chemicals.